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Showing results for fkbp and prostate
Search for FKBPL and Prostate instead (1 results)
FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.
Maeda K, Habara M, Kawaguchi M, Matsumoto H, Hanaki S, Masaki T, Sato Y, Matsuyama H, Kunieda K, Nakagawa H, Shimada M. Maeda K, et al. Mol Oncol. 2022 Feb;16(4):940-956. doi: 10.1002/1878-0261.13030. Epub 2021 Jun 19. Mol Oncol. 2022. PMID: 34057812 Free PMC article.
The growth of prostate cancer is dependent on the androgen receptor (AR), which serves as a ligand-specific transcription factor. ...Finally, elevated expression of FKBP52 was associated with a higher rate of prostate-specific antigen recurrence in patients with …
The growth of prostate cancer is dependent on the androgen receptor (AR), which serves as a ligand-specific transcription factor. ... …
Identification and validation of novel androgen-regulated genes in prostate cancer.
Velasco AM, Gillis KA, Li Y, Brown EL, Sadler TM, Achilleos M, Greenberger LM, Frost P, Bai W, Zhang Y. Velasco AM, et al. Endocrinology. 2004 Aug;145(8):3913-24. doi: 10.1210/en.2004-0311. Epub 2004 May 6. Endocrinology. 2004. PMID: 15131019
Androgen-regulated genes (ARGs) are essential for the development of the prostate. Ironically, ARGs are also responsible for the pathogenesis of prostate cancer. ...FKBP51 (FK506-binding immunophilin 51) was found in the same cluster as prostate-specif …
Androgen-regulated genes (ARGs) are essential for the development of the prostate. Ironically, ARGs are also responsible for the path …
ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells.
Komaragiri SK, Bostanthirige DH, Morton DJ, Patel D, Joshi J, Upadhyay S, Chaudhary J. Komaragiri SK, et al. Biochem Biophys Res Commun. 2016 Sep 9;478(1):60-66. doi: 10.1016/j.bbrc.2016.07.092. Epub 2016 Jul 25. Biochem Biophys Res Commun. 2016. PMID: 27462022 Free PMC article.
Deregulation of tumor suppressor genes is associated with tumorigenesis and the development of cancer. In prostate cancer, ID4 is epigenetically silenced and acts as a tumor suppressor. In normal prostate epithelial cells, ID4 collaborates with androgen receptor (AR …
Deregulation of tumor suppressor genes is associated with tumorigenesis and the development of cancer. In prostate cancer, ID4 is epi …
Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.
Jääskeläinen T, Makkonen H, Visakorpi T, Kim J, Roeder RG, Palvimo JJ. Jääskeläinen T, et al. Mol Cell Endocrinol. 2012 Mar 5;350(1):87-98. doi: 10.1016/j.mce.2011.11.025. Epub 2011 Dec 2. Mol Cell Endocrinol. 2012. PMID: 22155569
Since data-mining from the Oncomine database revealed that expression of histone H2B K120 monoubiquitin (H2Bub1) ligase RNF20 is decreased in metastatic prostate cancer, we elucidated the effect of RNF20 and its homolog RNF40 on androgen receptor (AR)-dependent transcripti …
Since data-mining from the Oncomine database revealed that expression of histone H2B K120 monoubiquitin (H2Bub1) ligase RNF20 is decreased i …
Steroid up-regulation of FKBP51 and its role in hormone signaling.
Jääskeläinen T, Makkonen H, Palvimo JJ. Jääskeläinen T, et al. Curr Opin Pharmacol. 2011 Aug;11(4):326-31. doi: 10.1016/j.coph.2011.04.006. Epub 2011 Apr 29. Curr Opin Pharmacol. 2011. PMID: 21531172 Review.
FK506 binding protein 51 (FKBP51, FKBP5) functions as a co-chaperone for androgen, glucocorticoid, mineralocorticoid and progesterone receptors. The FKBP51 can act as an important determinant of the responses to steroids, especially to glucocorticoids in stress and mood di …
FK506 binding protein 51 (FKBP51, FKBP5) functions as a co-chaperone for androgen, glucocorticoid, mineralocorticoid and progesterone …
Cotargeting Androgen Receptor and Clusterin Delays Castrate-Resistant Prostate Cancer Progression by Inhibiting Adaptive Stress Response and AR Stability.
Matsumoto H, Yamamoto Y, Shiota M, Kuruma H, Beraldi E, Matsuyama H, Zoubeidi A, Gleave M. Matsumoto H, et al. Cancer Res. 2013 Aug 15;73(16):5206-17. doi: 10.1158/0008-5472.CAN-13-0359. Epub 2013 Jun 20. Cancer Res. 2013. PMID: 23786771
Although androgen receptor (AR) pathway inhibitors prolong survival in castrate-resistant prostate cancer (CRPC), resistance rapidly develops and is often associated with increased stress-activated molecular chaperones like clusterin (CLU) and continued AR signaling. ...Co …
Although androgen receptor (AR) pathway inhibitors prolong survival in castrate-resistant prostate cancer (CRPC), resistance rapidly …
Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements.
Paulo P, Ribeiro FR, Santos J, Mesquita D, Almeida M, Barros-Silva JD, Itkonen H, Henrique R, Jerónimo C, Sveen A, Mills IG, Skotheim RI, Lothe RA, Teixeira MR. Paulo P, et al. Neoplasia. 2012 Jul;14(7):600-11. doi: 10.1593/neo.12600. Neoplasia. 2012. PMID: 22904677 Free PMC article.
This work aimed to evaluate whether ETS transcription factors frequently involved in rearrangements in prostate carcinomas (PCa), namely ERG and ETV1, regulate specific or shared target genes. We performed differential expression analysis on nine normal prostate tis …
This work aimed to evaluate whether ETS transcription factors frequently involved in rearrangements in prostate carcinomas (PCa), nam …
Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer.
Febbo PG, Lowenberg M, Thorner AR, Brown M, Loda M, Golub TR. Febbo PG, et al. J Urol. 2005 May;173(5):1772-7. doi: 10.1097/01.ju.0000155845.44729.ba. J Urol. 2005. PMID: 15821585
PURPOSE: Androgen ablation continues to be the most effective therapy for metastatic prostate cancer, although the biologically active androgen receptor (AR) target genes remain largely unknown. ...RESULTS: Many genes had expression that correlates with androgen stimulatio …
PURPOSE: Androgen ablation continues to be the most effective therapy for metastatic prostate cancer, although the biologically activ …
The prognostic value of stromal FK506-binding protein 1 and androgen receptor in prostate cancer outcome.
Leach DA, Trotta AP, Need EF, Risbridger GP, Taylor RA, Buchanan G. Leach DA, et al. Prostate. 2017 Feb;77(2):185-195. doi: 10.1002/pros.23259. Epub 2016 Oct 8. Prostate. 2017. PMID: 27718274
CONCLUSION: FKBP51 improves the ability of stromal AR to predict prostate cancer-specific mortality. By adding additional immunological assessment, similar to what is already in place in a number of other cancers, we could better serve patients with prostate cancer …
CONCLUSION: FKBP51 improves the ability of stromal AR to predict prostate cancer-specific mortality. By adding additional immunologic …
GPI-1485 (Guilford).
Marshall VL, Grosset DG. Marshall VL, et al. Curr Opin Investig Drugs. 2004 Jan;5(1):107-12. Curr Opin Investig Drugs. 2004. PMID: 14983983 Review.
GPI-1485 is a neuroimmunophilin ligand that binds to FK-506-binding proteins and is under development by Guilford for the potential treatment of erectile dysfunction following nerve injury during prostate resection and Parkinson's disease. ...
GPI-1485 is a neuroimmunophilin ligand that binds to FK-506-binding proteins and is under development by Guilford for the pote …
66 results